Oseltamivir (Tamiflu)-induced Bilateral Ciliochoroidal Effusion and Angle Closure Glaucoma: What Type of Idiosyncratic Reaction?

PURPOSE To report a case of bilateral acute angle closure glaucoma after one dose of oseltamivir 75 mg. CASE REPORT A 37-year-old man with a history of influenza developed high intraocular pressure and uniformly shallow anterior chamber in both eyes, 5 hours after the first dose of oseltamivir 75 mg. The condition was managed successfully with topical cycloplegic and systemic/topical antiglaucoma medications. CONCLUSION Since a presumed idiosyncratic reaction developed right after the first dose of the medication, it challenges the common concept of adaptive immune system involvement in this type of reaction in medication-related ciliochoroidal effusion.